Taysha Gene Therapies

Taysha Gene Therapies, Inc.is a patient-centric, clinical-stage gene therapy company, which engages in the development and commercialization of adeno-associated viruses (AAV) based gene therapies for the treatment of monogenic diseases of the central nervous system. It also develops multiple gene therapy platforms which include AAV9 Discovery, Novel Capsid, and AAV Redosing. The company was founded by Steven Gray, Berge Minassian, and R. A. Session II in 2019 and is headquartered in Dallas, TX.

Earnings data Q2 2023

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New preclinical data after neonatal administration in wild-type mice showed no detectable impact on survival, neurobehavioral functions and overall health, suggesting TSHA-102, engineered with novel miRARE technology, avoided toxic overexpression of MeCP2 within cells already expressing MeCP2

Taysha Gene Therapies Presents Preclinical Data on TSHA-102 for Rett Syndrome Demonstrating Cellular Regulation of MeCP2 Expression in Key Mouse Models at the American Society of Gene and Cell Therapy 26th Annual Meeting

Taysha Gene Therapies, Inc. (NASDAQ:TSHA ) Q1 2023 Earnings Conference Call May 11, 2023 4:30 PM ET Company Participants Hayleigh Collins - Director and Head of Corporate Communications Sean Nolan - CEO Sukumar Nagendran - President and Head of Research and Development Salman Bhai - Assistant Professor of Neurology at UT Kamran Alam - CFO Conference Call Participants Abigail Gray - Baird Gil Blum - Needham & Co. Operator Thank you for standing by. This is the conference operator.

Taysha Gene Therapies, Inc. (TSHA) Q1 2023 Earnings Call Transcript

Screening completed and dosing scheduled for first potential subject in the Phase 1/2 REVEAL trial in Rett syndrome; dosing of first adult patient with TSHA-102 expected in Q2 2023; initial available Phase 1/2 clinical data, primarily on safety, expected in Q2 2023

Taysha Gene Therapies Reports First Quarter 2023 Financial Results and Provides Corporate Update

DALLAS, May 04, 2023 (GLOBE NEWSWIRE) -- Taysha Gene Therapies, Inc. (Nasdaq: TSHA), a clinical-stage gene therapy company focused on developing and commercializing AAV-based gene therapies for the treatment of monogenic diseases of the central nervous system (CNS), today announced that it will report its financial results for the first quarter ended March 31, 2023, and host a corporate update conference call and webcast on Thursday, May 11, 2023, at 4:30 PM Eastern Time.

Taysha Gene Therapies to Release First Quarter 2023 Financial Results and Host Conference Call and Webcast on May 11

DALLAS, April 27, 2023 (GLOBE NEWSWIRE) -- Taysha Gene Therapies, Inc. (Nasdaq: TSHA), a clinical-stage gene therapy company focused on developing and commercializing AAV-based gene therapies for the treatment of monogenic diseases of the central nervous system (CNS), today announced that an abstract related to its TSHA-102 program in Rett syndrome was accepted for presentation at the upcoming American Society of Gene and Cell Therapy (ASGCT) 26th Annual Meeting, taking place in Los Angeles, CA from May 16-20, 2023. The abstract includes new preclinical data from a Taysha-sponsored study for TSHA-102, a self-complementary intrathecally delivered AAV9 gene transfer therapy in clinical evaluation for Rett syndrome, a rare neurodevelopmental disorder caused by mutations in the X-linked MECP2 gene.

Taysha Gene Therapies Announces Presentation on New Preclinical Data for TSHA-102 in Rett Syndrome at Upcoming American Society of Gene and Cell Therapy 26th Annual Meeting

Taysha Gene Therapies, Inc. (NASDAQ:TSHA ) Q4 2022 Earnings Conference Call March 28, 2023 4:30 PM ET Company Participants Hayleigh Collins - Director and Head of Corporate Communications Sean Nolan - Chief Executive Officer Sukumar Nagendran - President and Head of Research and Development Kamran Alam - Chief Financial Officer Conference Call Participants Whitney Ijem - Canaccord Genuity Jack Allen - Robert W. Baird & Co. Silvan Tuerkcan - JMP Securities Yun Zhong - BTIG David Hoang - SMBC Nikko Securities Joon Lee - Truist Securities Operator Greetings, and welcome to the Taysha Gene Therapies Fourth Quarter and Full-Year 2022 Earnings Call.

Taysha Gene Therapies, Inc. (TSHA) Q4 2022 Earnings Call Transcript

Initiated screening of first potential subject in Phase 1/2 REVEAL trial in Rett syndrome; dosing of first adult patient with TSHA-102 expected in H1 2023; submitted protocol amendment to allow for younger patients; initial available Phase 1/2 clinical data, primarily on safety, expected in H1 2023

Taysha Gene Therapies Reports Fourth Quarter and Full Year 2022 Financial Results and Provides Corporate Update

DALLAS, March 15, 2023 (GLOBE NEWSWIRE) -- Taysha Gene Therapies, Inc. (Nasdaq: TSHA), a patient-centric, clinical-stage gene therapy company focused on developing and commercializing AAV-based gene therapies for the treatment of monogenic rare diseases of the central nervous system (CNS), today announced that it will report its financial results for the fourth quarter and full-year ended December 31, 2022, and host a corporate update conference call and webcast on Tuesday, March 28, 2023, at 4:30 PM Eastern Time.

Taysha Gene Therapies to Release Fourth Quarter and Full-Year 2022 Financial Results and Host Conference Call and Webcast on March 28

Taysha has a good chance of scoring with the GAN indication. Astellas may license this program if that happens.

Taysha: The FDA Just Stuck A Major Blow To Their Plans

Type B end-of-Phase 2 meeting with U.S. Food and Drug Administration (FDA) provided additional clarity for TSHA-120 for the treatment of giant axonal neuropathy (GAN) ultra-rare disease program  - FDA acknowledged MFM32 as an acceptable endpoint with a recommendation to dose additional patients in a double-blind, placebo-controlled design to support Biologics License Application (BLA) submission

Taysha Gene Therapies Provides Update on TSHA-120 Program in Giant Axonal Neuropathy and a 2023 Corporate Outlook

Chair of the Board of Directors, Sean P. Nolan, appointed Chief Executive Officer

Taysha Gene Therapies Announces Executive Leadership Changes

Taysha Gene Therapies, Inc. (TSHA) witnesses a hammer chart pattern, indicating support found by the stock after losing some value lately. This coupled with an upward trend in earnings estimate revisions could mean a trend reversal for the stock in the near term.

Taysha Gene Therapies, Inc. (TSHA) Could Find Support Soon, Here's Why You Should Buy the Stock Now

DALLAS, Nov. 29, 2022 (GLOBE NEWSWIRE) -- Taysha Gene Therapies, Inc. (Nasdaq: TSHA), a patient-centric, pivotal-stage gene therapy company focused on developing and commercializing AAV-based gene therapies for the treatment of monogenic diseases of the central nervous system (CNS) in both rare and large patient populations, today announced that it will participate in the JMP Securities Hematology and Oncology Summit, which is taking place virtually from Tuesday, December 6, 2022, through Wednesday, December 7, 2022. Taysha's President, Founder and Chief Executive Officer, RA Session II, will participate in a fire side chat with Silvan Turkan, Ph.D., Senior Research Analyst at JMP Securities, at 3:40 PM ET on Wednesday, December 7, 2022.

Taysha Gene Therapies to Participate in JMP Securities Hematology and Oncology Summit

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Shares have fallen by 85% since Sept 2020 IPO as cash resources dwindled to $34M as of last month. Company was forced to cut 35% of workforce, stop construction of its cGMP manufacturing facility and focus on two lead clinical candidates.

Taysha Gene Therapies: Astellas Throws Lifeline For First Dibs On Rett And GAN Programs

Taysha Gene Therapies, Inc. (NASDAQ:TSHA ) Q3 2022 Results Earnings Conference Call November 8, 2022 8:00 AM ET Company Participants Kimberly Lee - Chief Corporate Affairs Officer RA Session - President, Founder and Chief Executive Officer Suyash Prasad - Chief Medical Officer and Head of Research and Development Kamran Alam - Chief Financial Officer Fred Porter - Chief Technical Officer Conference Call Participants Gil Blum - Needham & Company, LLC Geulah Livshits - Chardan Mehdi Goudarzi - Truist Securities Michael Ulz - Morgan Stanley David Hoang - SMBC Nikko Benjamin Paluch - Robert W. Baird Yanan Zhu - Wells Fargo Tiffany Marchell - William Blair Whitney Ijem - Canaccord Genuity Operator Thank you for standing by.

Taysha Gene Therapies, Inc. (TSHA) Q3 2022 Results - Earnings Call Transcript

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$50 million strategic investment from Astellas Pharma to support development of TSHA-120 in giant axonal neuropathy (GAN) and TSHA-102 in Rett syndrome

Taysha Gene Therapies Reports Third Quarter 2022 Financial Results and Provides Corporate Update

In their previous filing dated October 5, 2020 they reported 5,295,307 shares and 14.30% of the company, an increase in shares of 32.00% and a decrease in total ownership of 3.10% (calculated as current – previous percent ownership).

Paul Manning increases stake in Taysha Gene Therapies Inc (TSHA)

DALLAS, Nov. 02, 2022 (GLOBE NEWSWIRE) -- Taysha Gene Therapies, Inc. (Nasdaq: TSHA), a patient-centric, pivotal-stage gene therapy company focused on developing and commercializing AAV-based gene therapies for the treatment of monogenic diseases of the central nervous system (CNS) in both rare and large patient populations, today announced that it will report its financial results for the third quarter ended September 30, 2022, and host a corporate update conference call and webcast on Tuesday, November 8, 2022, at 8:00 AM Eastern Time.

Taysha Gene Therapies to Release Third Quarter 2022 Financial Results and Host Conference Call and Webcast on November 8

DALLAS, Oct. 26, 2022 (GLOBE NEWSWIRE) -- Taysha Gene Therapies, Inc. (Nasdaq: TSHA) (“Taysha”), a patient-centric, pivotal-stage gene therapy company focused on developing and commercializing AAV-based gene therapies for the treatment of monogenic diseases of the central nervous system (CNS) in both rare and large patient populations, today announced the pricing of an underwritten public offering of 14,000,000 shares of its common stock at a price to the public of $2.00 per share. In addition, Taysha has granted the underwriter a 30-day option to purchase up to 2,100,000 additional shares of common stock at the public offering price, less the underwriting discount. The gross proceeds from the offering to Taysha are expected to be approximately $28.0 million, before deducting underwriting discounts and commissions and other offering expenses, excluding any exercise of the underwriter's option to purchase additional shares. The offering is expected to close on or about October 31, 2022, subject to customary closing conditions.

Taysha Announces Pricing of Public Offering of Common Stock

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DALLAS, Oct. 25, 2022 (GLOBE NEWSWIRE) -- Taysha Gene Therapies, Inc. (Nasdaq: TSHA), a patient-centric, pivotal-stage gene therapy company focused on developing and commercializing AAV-based gene therapies for the treatment of monogenic diseases of the central nervous system (CNS) in both rare and large patient populations, today announced that it intends to offer and sell, subject to market conditions, $30 million of shares of its common stock in an underwritten public offering. All shares of common stock to be sold in the offering will be offered by Taysha. Taysha also intends to grant the underwriter a 30-day option to purchase up to an additional 15% of the shares of its common stock offered in the public offering under the same terms and conditions. The offering is subject to market conditions, and there can be no assurance as to whether or when the offering may be completed, or the actual size or terms of the offering.

Taysha Gene Therapies Announces Proposed Public Offering of Common Stock

Taysha Gene Therapies (NASDAQ: TSHA ) jumped 50% overnight after Japan's Astellas Pharma (OTCMKTS: ALPMY ) bought 15% of the company and exclusive marketing rights to its genetic therapies. Taysha is working on two Adeno Associated Virus (AAV) therapies for genetic brain disorders.

What Is Going on With Taysha Gene (TSHA) Stock Today?

Conference call and webcast on Tuesday, October 25 at 8:00 AM ET Conference call and webcast on Tuesday, October 25 at 8:00 AM ET

Taysha Gene Therapies to Host Conference Call to Discuss Astellas Pharma's Strategic Investment to Support the Development of Taysha's AAV-based Gene Therapy Programs

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